Hotel Only You Atocha
8:00h – 9:00h
Chairs: J Scarisbrick, E Guenova, E Papadavid
***Closed meeting, only under invitation
9:00h – 10:00h
Breakup meeting UV treatments for cutaneous lymphoma
Chairs: S Whittaker, J Latzka
***Closed meeting, only under invitation
10:00h – 11:00h
Chairs: M Vermeer, S Najidh
***Closed meeting, only under invitation
11:00h – 12:00h
Patch/plaque project
Chairs: J Scarisbrick, P Quaglino. M Bagot, E Hodak
***Closed meeting, only under invitation
12:00h Transfer Only You Atocha Hotel – Hospital
12:45h Lunch at Hospital
13:25h Opening Ceremony
Dra. Carmen Martínez de Pancorbo
Prof. Julia Scarisbrick
Dr. PL Ortiz-Romero

A multi-level analysis of chlormethine: from skin cells to clinical cases
Chair Co-Chair
Pablo L Ortiz-Romero
Hospital 12 de Octubre, Universidad Complutense, Madrid Medical School, Madrid, Spain
Emmanuella Guenova
University of Lausanne,
Lausanne, Switzerland
To summarize the data available regarding the mechanism of action of chlormethine (CL) gel, and discuss its potential use as a combination therapy for patients with mycosis fungoides (MF)
13:30 – 13:35 Opening and welcome
Pablo L Ortiz-Romero
13:35 – 13:50 The skin level: Release, permeation, and pharmacokinetics of chlormethine (CL) gel
Pablo L Ortiz-Romero
13:50 – 14:05 The molecular level: The mode of action of CL gel and impact on T cells
Emmanuella Guenova
14:05 – 14:15 The patient level: An expert interview on how to utilise CL gel in real clinical practice
Emmanuella Guenova, interviewed by Pablo L Ortiz-Romero
14:15 – 14:25 Interactive Q&A session
Emmanuella Guenova and Pablo L Ortiz-Romero, moderated by Pablo L Ortiz-Romero
14:25 – 14:30 Closing remarks
Pablo L Ortiz-Romero

Oral Presentations 01. Biologic insights
Chairs: M Vermeer, M Bagot, J Guitart
14:30h BioIns-O-01 Immunophenotypic identification and characterization of CTCL tumor cells in blood using standardized flow cytometry: A European Multicenter Study
S Najih
Leiden University Medical Center (LUMC), Leiden, The Nederlands
14:42h BioIns-O-02 Targeting immunosuppressive macrophages in the cutaneous T-cell lymphoma microenvironment.
CP Portocarrero
Department of Dermatology and Cutaneous Biology. Thomas Jefferson University, Philadelphia, USA
14:54h BioIns-O-03 Whole-genome profiling of primary cutaneous anaplastic large cell lymphoma.
CP Tensen
Leiden University Medical Center (LUMC), Leiden, The Nederlands
15:06h BioIns-O-04 POT1 gene dysfunction in Primary Cutaneous T-cell Lymphoma.
F Bakr
Guys and St Thomas’s NHS Trust, London, UK
15:18h BioIns-O-05 Dual blocking of CD47 and PD-L1 increases innate and adaptive immune responses in CTCL.
C Querfeld
City of Hope Cancer Center and Beckman Research Institute, Duarte, CA, USA
15:30h Coffee Break

Oral Presentations 2. Biologic insights
Chairs: Y kim, JP Merlio. E Guenova
16:00 BioIns-O-06 Single-cell RNA sequencing reveals race-based heterogeneity of malignant T-cells and skin microenvironment in patients with cutaneous T-cell lymphoma.
D Weiner
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, USA
16:12 BioIns-O-07 Mycosis Fungoides: molecular identity revealed by nanostring analysis.
R Alonso Alonso
Department of Pathology, Fundación Jiménez Díaz, Madrid, Spain
16:24 BioIns-O-08 Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior.
JG Griss
Medical University of Vienna, Vienna
16:36 BioIns-O-09 Risk of progression of early-stage mycosis fungoides from RNA analysis.
V Gargallo Moneva
Service of Dermatology, Hospital del Sureste, Madrid
16:48 BioIns-O-10 Boost of innate immunity cytokines as biomarkers of response to extracorporeal photopheresis in leukemic cutaneous T-cell lymphoma patients.
YCT Tsai
Department of Dermatology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

Oral Presentations 3. Biologic insights
Chairs: R Willemze, J Choi, F Gallardo
17:00h BioIns-O-11 Combination of JAKi and MAPKi exerts antiangionenic potential in Cutaneous T-cell Lymphoma.
F Karagianni
National Center of Rare Diseases-Cutaneous Lymphoma, Second Department of Dermatology and Venereal Diseases, Attikon University General Hospital, Athens
17:12h BioIns-O-12 Cutaneous Lymphocyte Antigen (CLA) is a potential therapeutic target in Cutaneous T Cell Lymphoma.
S Poglio
BRIC (Bourdeaux Institute of Oncology), UMR1312, INSERM, Univ. Bordeaux, F-33000, Bordeaux, France
17:24h BioIns-O-13 Proliferative tumor infiltrating lymphocytes within microenvironment impact prognosis in cutaneous B-cell lymphomas.
A Pham-Ledard
BRIC (Bourdeaux Institute of Oncology), UMR1312, INSERM, Univ. Bordeaux, F-33000, Bordeaux, France
17:36h BioIns-O-14 Translational research linked to PIMTO-MF clinical.
PL Ortiz-Romero
Department of Dermatology, Hospital Universitario 12 de Octubre, Medical School, Institute i+12, CIBERONC, University Complutense Madrid, Madrid
17:48h BioIns-O-15 CCR8 is a new therapeutic target in cutaneous T-cell lymphomas.
A De Masson
INSERM U976, Sant-Louis Hospital, Paris, France

Oral Presentations 4. Histopathology
Chairs: M Battistella, A Gru, W Kempf
18:00h Hist-O-01 Artificial intelligence-assisted probability scoring for differentiation of early mycosis fungoides and benign inflammatory dermatoses on H&E-stained pathology slides of skin biopsies.
T Doeleman
Leiden University Medical Center (LUMC), Leiden, The Nederlands
18:12h Hist-O-02 Identifying unmet needs and challenges in the definition of a plaque in mycosis fungoides: an EORTC-CLG/ISCL survey.
P Quaglino
Clinic of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy
18:24h Hist-O-03 Different subtypes of lymphomatoid papulosis are more overlapping than expected – an analysis of published histologic patterns and criteria.
T Fricke
University Medical Center Goettingen, Department of Dermatology, Veneorology and Allergology, Goettingen, Germany
18:36h Hist-O-04 Aggressive cytotoxic dermal lymphomas of the earlobe: a single-institution case series.
J Guitart
Department of Dermatology, Northwestern University, Chicago, USA
18:48h Hist-O-05 Histiocytoid Sweet’s Syndrome in a patient with myelodysplastic syndrome with multilineage dysplasia (MDS-MLD), and monoclonal gammopathy of undetermined significance (MGUS) IgG kappa type.
O Pavlova
Department of Dermatology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
19:00h Poster session 1. Poster walk
Selected authors should be present to explain their posters
BioIns-PO-03 IL32β supports the HLA I expression on tumor skin T lymphocytes as a tumor immune escape mechanism in cutaneous T-cell lymphoma
YT Chang
Department of Dermatology, Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland
BioIns-PO-5 Unraveling tumor micro-environment by cellular and proteome analyses of suction blister fluid of early-stage mycosis fungoides lesions compared to non-lesional skin over time on chlormethine gel treatment using flow cytometry.
SS Wind
Leiden University Medical Center (LUMC), Leiden, The Nederlands
BioIns-PO-09 Elevated A-to-I RNA editing in leukemic cutaneous T-cell lymphoma.
L Moyal
Department of Dermatology, Rabin Medical Center and Felsenstein Research Center, Tel-Aviv University, Israel
Clin-PO-05 Illness perception of early-stage mycosis fungoides among dermatologists:
a multi-center cross-sectional study
A Barzilai
Department of Dermatology, Sheba Medical Center, Tel Aviv, Israel
20:15h Transfer Hospital – Only You Atocha Hotel